反应详情

To a stirred solution of 15.0 g of 2-aminobenzophenone in 7.5 cc of pyridine was added 14.5 g of p-toluenesulfonyl chloride under ice-cooling. And the resulting mixture was stirred at room temperature for 16 hours. 2N HCl was added to the reaction mixture and extracted with ethyl acetate. The extract was washed with water and dried over magnesium sulfate. The solvent was distilled off and the crude crystals thus obtained were recrystallized from isopropanol to obtain 22.0 g of compound H. Yield: 82.4%.

1. temperaturecooling
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water
4. dry with materialdried over magnesium sulfate
5. distillationThe solvent was distilled off
6. customthe crude crystals thus obtained
7. customwere recrystallized from isopropanol