HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Chloro-6-methyl-4-(1-methyl-3-trifluoromethyl-5-pyrazolyloxy)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,4-Dichloro-6-methylpyrimidine | HCID 79471 | — |
| Reactant | 1-Methyl-3-trifluoromethyl-2-pyrazolin-5-one | HCID 518566 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Chloro-6-methyl-4-(1-methyl-3-trifluoromethyl-5-pyrazolyloxy)pyrimidine | HCID 53771522 | 68% |
Reaction Steps
5 g 2,4-Dichloro-6-methylpyrimidine, 5.3 g 1-methyl-3-trifluoromethyl-2-pyrazolin-5-one, and 6.2 g potassium carbonate in 100 mL dry acetonitrile are refluxed for 2 hours. The mixture is poured into water, extracted with ethyl acetate and chromatographed to give 6.1 g of the title compound (m.p. 65° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05747423 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-956103f789a3405da63494fb069f5f46 |
| Source note | uspto-grants-1998_05 |