Water → HCID 10991979, compound

HRID 1288670Notes

Reaction equation

HRID 1288670 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:12]=[C:11](Cl)[CH:10]=[C:9]([Cl:14])[N:8]=2)=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:21]=[C:20]([OH:22])[CH:19]=[CH:18][N:17]=1.C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([Cl:14])[CH:10]=[C:11]([O:22][C:20]3[CH:19]=[CH:18][N:17]=[C:16]([Cl:15])[CH:21]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 11032782HCID 11032782, compoundHCID 178516507HCID 178516507, compound

Product 1

HCID 10991979HCID 10991979, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.4 g 2-(5-Chloro-2-thienyl)-4,6-dichloropyrimidine, 0.2 g 2-Chloro-4-hydroxypyridine, and 0.3 g potassium carbonate are refluxed in 30 mL dry acetonitril for 16 hours. The mixture is poured into water, and the product is extracted with toluene and purified by flash chromatography (0.38 g, m.p. 154°-156° C.).

Workup

  1. extractionthe product is extracted with toluene
  2. custompurified by flash chromatography (0.38 g, m.p. 154°-156° C.)

Sources & evidence

ORD record
ord-2b79cb9891d94a58b8a4b2fc3e7b0fe4
Source dataset
uspto-grants-1998_05
Patent number
US05747423

Reaction notes

Loading…