反应详情

To a stirred solution of 2.55 g of compound J in 10 cc of methylene chloride was added 2.20 g of trichloroacetic acid under ice-cooling and the mixture was stirred for 16 hours. Water was added to the reaction mixture, the desired compound was extracted with ethyl acetate. The extract was dried over magnesium sulfate and distilled to remove the solvent. The crude product thus obtained was purified by a silica gel column chromatography (eluent: ethyl acetate/hexane=3/7) to obtain 2.10 g of 3-phenyl-1-(p-toluenesulfonyl)indole-2-carboxylic acid. Yield: 94.1%.

1. temperaturecooling
2. extractionthe desired compound was extracted with ethyl acetate
3. dry with materialThe extract was dried over magnesium sulfate
4. distillationdistilled
5. customto remove the solvent
6. customThe crude product thus obtained
7. customwas purified by a silica gel column chromatography (eluent: ethyl acetate/hexane=3/7)