1H-1,2,4-Triazole → HCID 17878451, compound

HRID 1288821Notes

Reaction equation

HRID 1288821 reaction equation
Cl[CH2:2][C:3]1[N:8]=[C:7]2[S:9][C:10]([CH3:13])=[C:11]([CH3:12])[C:6]2=[C:5]([C:14]2[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=2)[C:4]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24].[NH:28]1[CH:32]=[N:31][CH:30]=[N:29]1>>[CH3:13][C:10]1[S:9][C:7]2=[N:8][C:3]([CH2:2][N:28]3[CH:32]=[N:31][CH:30]=[N:29]3)=[C:4]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[C:5]([C:14]3[CH:19]=[CH:18][C:17]4[O:20][CH2:21][O:22][C:16]=4[CH:15]=3)=[C:6]2[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 18924857HCID 18924857, compound

Product 1

HCID 17878451HCID 17878451, compound

Procedure

In substantially the same manner as in Example 2, ethyl 6-chloromethyl-4-(3,4-methylenedioxyphenyl)-2,3-dimethylthieno[2,3-b]pyridine-5-carboxylate was allowed to react with 1H-1,2,4-triazole to produce ethyl 2,3-dimethyl-4-(3,4-methylenedioxyphenyl)-6-(1,2,4-triazol-1-ylmethyl)thieno[2,3-b]pyridine-5-carboxylate. Recrystallization from ethyl acetate-hexane gave colorless prisms, m.p.109°-110° C.

Sources & evidence

ORD record
ord-8551636205e24cdaa48907805a101653
Source dataset
uspto-grants-1998_05
Patent number
US05747486

Reaction notes

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