Sodium → HCID 178462377, compound

HRID 128883Notes

Reaction equation

FC(F)(F)C([O-])=O.C([NH:27][C:28]1[S:29][CH:30]=[C:31](/[C:33](=[N:71]/[O:72][C@H:73]([C:75]([O:77]C(C2C=CC=CC=2)C2C=CC=CC=2)=[O:76])[CH3:74])/[C:34]([NH:36][CH:37]2[C:69](=[O:70])[N:39]3[C:40]([C:57]([O:59]CC4C=CC(OC)=CC=4)=[O:58])=[C:41]([CH2:44][S:45][C:46]4[N+:47]([CH3:56])=[C:48]5[CH:53]=[CH:52][N:51]([CH3:54])[CH:50]=[C:49]5[N:55]=4)[CH2:42][S:43][C@H:38]23)=[O:35])[N:32]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Na]>>[NH2:27][C:28]1[S:29][CH:30]=[C:31](/[C:33](=[N:71]/[O:72][C@H:73]([C:75]([OH:77])=[O:76])[CH3:74])/[C:34]([NH:36][CH:37]2[C:69](=[O:70])[N:39]3[C:40]([C:57]([O-:59])=[O:58])=[C:41]([CH2:44][S:45][C:46]4[N+:47]([CH3:56])=[C:48]5[CH:53]=[CH:52][N:51]([CH3:54])[CH:50]=[C:49]5[N:55]=4)[CH2:42][S:43][C@H:38]23)=[O:35])[N:32]=1

Participants

Reactant 2

HCID 5360545Sodium

HCID 178491526HCID 178491526, compound

Product 1

HCID 178462377HCID 178462377, compoundYield 52.5%

Procedure

Using 334 mg of p-methoxybenzyl 7-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-{(S)-1-diphenylmethoxycarbonylethoxyimino}acetamido]-3-(1,5-dimethylimidazolo[4,5-c]pyridinium-2-yl)thiomethyl-3-cephem-4-carboxylate trifluoroacetate as a starting material, the reaction and purification were carried out in the same manner as in Example 1(b) to obtain 87 mg of the title compound in the form of a sodium salt in a yield of 51%.

Workup

customthe reaction and purification

Sources & evidence

ORD record: ord-024a9568ad134237a9a2313146b0c9f7
Source dataset: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05464829

Reaction notes

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