HRID128883

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5360545

Sodium

$反应SMILES：COc1ccc(COC(=O)C2=C(CSc3nc4cn(C)ccc-4[n+]3C)CS[C@@H]3C(NC(=O)/C(=N\O[C@@H](C)C(=O)OC(c4ccccc4)c4ccccc4)c4csc(NC(c5ccccc5)(c5ccccc5)c5ccccc5)n4)C(=O)N23)cc1.O=C([O-])C(F)(F)F$

HCID178491526

未命名化合物

PRODUCTS

产物

$反应SMILES：C[C@H](O/N=C(\C(=O)NC1C(=O)N2C(C(=O)[O-])=C(CSc3nc4cn(C)ccc-4[n+]3C)CS[C@H]12)c1csc(N)n1)C(=O)O$

HCID178462377

未命名化合物

收率 52.5%

PROCEDURE

实验过程

Using 334 mg of p-methoxybenzyl 7-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-{(S)-1-diphenylmethoxycarbonylethoxyimino}acetamido]-3-(1,5-dimethylimidazolo[4,5-c]pyridinium-2-yl)thiomethyl-3-cephem-4-carboxylate trifluoroacetate as a starting material, the reaction and purification were carried out in the same manner as in Example 1(b) to obtain 87 mg of the title compound in the form of a sodium salt in a yield of 51%.

WORKUP

后处理

customthe reaction and purification

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-024a9568ad134237a9a2313146b0c9f7
来源数据集: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05464829
来源说明: uspto-grants-1995_11

反应SMILES

FC(F)(F)C([O-])=O.C([NH:27][C:28]1[S:29][CH:30]=[C:31](/[C:33](=[N:71]/[O:72][C@H:73]([C:75]([O:77]C(C2C=CC=CC=2)C2C=CC=CC=2)=[O:76])[CH3:74])/[C:34]([NH:36][CH:37]2[C:69](=[O:70])[N:39]3[C:40]([C:57]([O:59]CC4C=CC(OC)=CC=4)=[O:58])=[C:41]([CH2:44][S:45][C:46]4[N+:47]([CH3:56])=[C:48]5[CH:53]=[CH:52][N:51]([CH3:54])[CH:50]=[C:49]5[N:55]=4)[CH2:42][S:43][C@H:38]23)=[O:35])[N:32]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Na]>>[NH2:27][C:28]1[S:29][CH:30]=[C:31](/[C:33](=[N:71]/[O:72][C@H:73]([C:75]([OH:77])=[O:76])[CH3:74])/[C:34]([NH:36][CH:37]2[C:69](=[O:70])[N:39]3[C:40]([C:57]([O-:59])=[O:58])=[C:41]([CH2:44][S:45][C:46]4[N+:47]([CH3:56])=[C:48]5[CH:53]=[CH:52][N:51]([CH3:54])[CH:50]=[C:49]5[N:55]=4)[CH2:42][S:43][C@H:38]23)=[O:35])[N:32]=1