Benzenamine, 3-ethynyl- → HCID 18925061, compound

HRID 1288862Notes

Reaction equation

HRID 1288862 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:14][CH2:13][O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:15]([C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][CH:23]=1)[NH2:20])#[CH:16]>C(O)(C)C>[ClH:1].[C:15]([C:17]1[CH:18]=[C:19]([NH:20][C:2]2[C:11]3[C:6](=[CH:7][C:8]4[O:14][CH2:13][O:12][C:9]=4[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:21]=[CH:22][CH:23]=1)#[CH:16]

Participants

4

Reactant 2

HCID 104682Benzenamine, 3-ethynyl-HCID 149353678-Chloro-2H-[1,3]dioxolo[4,5-g]quinazoline

Product 1

HCID 18925061HCID 18925061, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-Chloro-6,7-methylenedioxyquinazoline (200 mg, 1.04 mmol) and 3-ethynylaniline (127 mg, 1.09 mmol) were refluxed in 5 mL of isopropyl alcohol for 16 hour, cooled and filtered to afford solid title product which was washed with 10 mL of isopropyl alcohol and dried in vacuo at 70° C., 266 mg (79%); mp >350° C.

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-63e10c6e027246799671da8535aa08d2
Source dataset
uspto-grants-1998_05
Patent number
US05747498

Reaction notes

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