Benzenamine, 3-ethynyl- → (3-Ethynylphenyl)-(7-nitroquinazolin-4-yl)-amine Hydrochloride

HRID 1288863ノート

反応式

HRID 1288863 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:15]([C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][CH:23]=1)[NH2:20])#[CH:16]>C(O)(C)(C)C>[ClH:1].[C:15]([C:17]1[CH:18]=[C:19]([NH:20][C:2]2[C:11]3[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:21]=[CH:22][CH:23]=1)#[CH:16]

参加物

4

反応物 2

HCID 104682Benzenamine, 3-ethynyl-HCID 8306804-Chloro-7-nitroquinazoline

生成物 1

HCID 18925068(3-Ethynylphenyl)-(7-nitroquinazolin-4-yl)-amine Hydrochloride

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

4-Chloro-7-nitroquinazoline (7.97 g, 38.0 mmol) and 3-ethynylaniline (4.54 g, 38.8 mmol) were refluxed in 125 mL of tert-butyl alcohol for 3 hours, cooled to room temperature and filtered to afford the title product as a solid which was washed with 10 mL of isopropyl alcohol and dried in vacuo at 70° C., 9.95 g (80%); mp 209°-210° C. dec.

後処理

  1. filtrationfiltered

出典と根拠

ORDレコード
ord-b770731fdc954e85963ca226cde69cce
出典データセット
uspto-grants-1998_05
特許番号
US05747498

反応ノート

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