Hydrochloric Acid → HCID 67715596, compound

HRID 1289107Notes

Reaction equation

HRID 1289107 reaction equation
[NH2:1][N:2]=[CH:3][C:4]1[CH:29]=[CH:28][C:7]([C:8]([NH:10][C@@H:11]([CH3:27])[C:12]([NH:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]([O:22]CCCC)=[O:21])=[O:13])=[O:9])=[CH:6][CH:5]=1.[ClH:30]>>[ClH:30].[NH2:1][N:2]=[CH:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][C@@H:11]([CH3:27])[C:12]([NH:14][CH2:15][CH2:16][CH2:17][O:18][CH2:19][C:20]([OH:22])=[O:21])=[O:13])=[O:9])=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86748358HCID 86748358, compound

Product 1

HCID 67715596HCID 67715596, compound

Procedure

416 mg of butyl (S)-[3-[2-[4-(aminoiminomethyl)benzoylamino]propionylamino]propoxy]acetate are stirred at 20° C. in 8.3 ml of 25 percent hydrochloric acid. The solution is evaporated and the residue is evaporated with water. From THF there are obtained 211 mg of (S)-[3-[2-[4-(aminoimino-methyl) benzoylamino]propionylamino]propoxy]acetic acid hydrochloride as the hydrate (1:1), m.p. 89°-90° C., [α]D20 =+23.4° (c=0.5 in methanol).

Workup

  1. customThe solution is evaporated
  2. customthe residue is evaporated with water

Sources & evidence

ORD record
ord-39b19cf164494fb1a9cc1ff18edd447d
Source dataset
uspto-grants-1998_05
Patent number
US05747522

Reaction notes

Loading…