Sodium Acetate → HCID 86752512, compound

HRID 1289165Notes

Reaction equation

HRID 1289165 reaction equation
[C:1]([C:9]1[CH:24]=[CH:23][C:12]([CH2:13][O:14][C:15]2[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=2)[CH:18]=O)=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:25]1[CH2:31][C:29](=[O:30])[NH:28][C:26]1=[S:27].C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:9]1[CH:24]=[CH:23][C:12]([CH2:13][O:14][C:15]2[CH:16]=[C:17]([CH:18]=[C:31]3[S:25][C:26](=[S:27])[NH:28][C:29]3=[O:30])[CH:20]=[CH:21][CH:22]=2)=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 21191286HCID 21191286, compound

Product 1

HCID 86752512HCID 86752512, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 3-(4-benzoylbenzyloxy)benzaldehyde (2.0 g, 6.3 mmol) was coupled with rhodanine (1.06 g, 8.0 mmol) in the presence of sodium acetate (1.89 g, 22 mmol) and acetic acid (75 ml) essentially as previously described to yield 1.6 grams (59.0%) of the deisred title product. mp 212.5°-213.5° C. NMR. FDMS (M+) 431.

Sources & evidence

ORD record
ord-2a0ca870e5c041628742580efbbd9c76
Source dataset
uspto-grants-1998_05
Patent number
US05747517

Reaction notes

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