HRID1289173

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID240

Benzaldehyde

C7H6O

HCID517045

Sodium Acetate

C2H3NaO2

HCID1201546

Rhodanine

C3H3NOS2

2 次

结构：CCCCCCCCCC(=O)c1ccc(OCc2ccc(C=O)cc2)c(CCC)c1O

HCID21191247

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCC(=O)c1ccc(OCc2ccc(C=C3SC(=S)NC3=O)cc2)c(CCC)c1O

HCID86752517

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

The 4-[(4-decanoyl-3-hydroxy-2-propylphenoxy)methyl]benzaldehyde thus obtained was coupled with the rhodanine by reacting equimolar amounts of the benzaldehyde and the rhodanine in the presence of sodium acetate and acetic acid as previously described to yield 1.6 g (84%) of the title product. mp 187.5°-188° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eb48911af1234711b90eb155eab65fba
来源数据集: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05747517
来源说明: uspto-grants-1998_05

反应 SMILES

[C:1]([C:12]1[CH:27]=[CH:26][C:15]([O:16][CH2:17][C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)=[C:14]([CH2:28][CH2:29][CH3:30])[C:13]=1[OH:31])(=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[S:32]1[CH2:38][C:36](=[O:37])[NH:35][C:33]1=[S:34].C(=O)C1C=CC=CC=1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:12]1[CH:27]=[CH:26][C:15]([O:16][CH2:17][C:18]2[CH:25]=[CH:24][C:21]([CH:22]=[C:38]3[S:32][C:33](=[S:34])[NH:35][C:36]3=[O:37])=[CH:20][CH:19]=2)=[C:14]([CH2:28][CH2:29][CH3:30])[C:13]=1[OH:31])(=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]