Sodium Acetate → HCID 86752518, compound

HRID 1289174Notes

Reaction equation

HRID 1289174 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[S:20]1[CH2:26][C:24](=[O:25])[NH:23][C:21]1=[S:22].C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[CH:13]=[CH:14][C:15]([CH:16]=[C:26]3[S:20][C:21](=[S:22])[NH:23][C:24]3=[O:25])=[CH:18][CH:19]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 21191250HCID 21191250, compound

Product 1

HCID 86752518HCID 86752518, compoundYield 52.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 4-[4-(t-butyl)phenylthio]benzaldehyde (1.5 g, 5.5 mmol) was coupled with rhodanine (0.87 g, 6.5 mmol) in the presence of sodium acetate (1.64 g, 20 mmol) and acetic acid (80 ml) essentially as previously described to yield 1.1 grams (52.3%) of the title product. mp 211°-212° C. NMR. FDMS (M+) 385.

Sources & evidence

ORD record
ord-e97db10243d145989ad6f35a00f67a8b
Source dataset
uspto-grants-1998_05
Patent number
US05747517

Reaction notes

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