Sodium Acetate → HCID 86752519, compound

HRID 1289175Notes

Reaction equation

HRID 1289175 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[CH:19]=[CH:18][C:15](C=O)=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[S:20]1[CH2:26][C:24](=[O:25])[NH:23][C:21]1=[S:22].[C:27]([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[CH:13]=[C:14]([CH:27]=[C:26]3[S:20][C:21](=[S:22])[NH:23][C:24]3=[O:25])[CH:15]=[CH:18][CH:19]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 21191250HCID 21191250, compound

Product 1

HCID 86752519HCID 86752519, compoundYield 66.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 4-[4-(t-butyl)phenylthio]benzaldehyde (1.5 g, 5.5 mmol) was condensed with rhodanine (0.865 g, 6.5 mmol) using sodium acetate (1.64 g, 20 mmol) and acetic acid (80 ml) essentially as previously described to yield 1.4 grams (66.7%) of the title compound. mp 188.5°-189.5° C. NMR. FDMS (M+) 385.

Sources & evidence

ORD record
ord-f717975db28f4519b0828388a4ea2697
Source dataset
uspto-grants-1998_05
Patent number
US05747517

Reaction notes

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