HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine → HCID 15841104, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine | HCID 3520 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | HCID 15841102 | HCID 15841102 | — |
| Reactant | HCID 15841103 | HCID 15841103 | — |
| Reactant | Potassium trifluoroacetate | HCID 23662811 | — |
| Catalyst | Tetramethylammonium iodide | HCID 6381 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 15841104 | HCID 15841104 | — |
Reaction Steps
A solution of 0.5 g of 2-methyl-4-phenoxy5-trifluoromethylbenzoic acid [obtainable by reaction of methyl 2-methyl-4-phenoxy-5-bromobenzoate with potassium trifluoroacetate in the presence of Cul and tetramethylammonium iodide and subsequent hydrolysis] and 300 mg of carbonyldiimidazole in 15 ml of THF is stirred at room temperature for two hours and then added to 383 mg of guanidine. The mixture is stirred for a further two hours. After customary working up, N-diaminomethylene-2-methyl-4-phenoxy-5-trifluoromethylbenzamide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05747539 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-d6bba8111a0248c1b7b81e7ae27eeeac |
| Source note | uspto-grants-1998_05 |