反应详情

温度

50 °C

A mixture of 5-acetamido-6-cyanoindan (104 g), hydrogen peroxide (30% solution in water, 400 ml), sodium hydroxide (35 g), water (200 ml) and ethanol (1 L) was stirred and heated to 50° C. for 1 hour. The mixture was cooled to ambient temperature and evaporated. The residue was dissolved in water (2 L) and the solution was acidified to pH 5 by the addition of 2N aqueous hydrochloric acid. The precipitate was isolated, washed with water and dried under vacuum. There was thus obtained 2-methyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-4-one (100 g), m.p. 284° C.

1. temperatureThe mixture was cooled to ambient temperature
2. customevaporated
3. dissolutionThe residue was dissolved in water (2 L)
4. additionthe solution was acidified to pH 5 by the addition of 2N aqueous hydrochloric acid
5. customThe precipitate was isolated
6. washwashed with water
7. customdried under vacuum