Pentafluorophenol → HCID 135480233, compound

HRID 1289231Notes

Reaction equation

HRID 1289231 reaction equation
[CH3:1][C:2]1[NH:11][C:10](=[O:12])[C:9]2[C:4](=[CH:5][C:6]3[CH2:15][CH2:14][CH:13]([N:16]([C:20]4[CH:37]=[CH:36][C:23]([C:24](N[C@H](C(O)=O)CCC(O)=O)=[O:25])=[CH:22][CH:21]=4)[CH2:17][C:18]#[CH:19])[C:7]=3[CH:8]=2)[N:3]=1.CC1NC(=O)C2C(=CC3CCC(N(C4C=CC(C(O)=O)=CC=4)CC#C)C=3C=2)N=1.[F:66][C:67]1[C:72]([OH:73])=[C:71]([F:74])[C:70]([F:75])=[C:69]([F:76])[C:68]=1[F:77]>>[CH3:1][C:2]1[NH:11][C:10](=[O:12])[C:9]2[C:4](=[CH:5][C:6]3[CH2:15][CH2:14][CH:13]([N:16]([C:20]4[CH:37]=[CH:36][C:23]([C:24]([O:73][C:72]5[C:71]([F:74])=[C:70]([F:75])[C:69]([F:76])=[C:68]([F:77])[C:67]=5[F:66])=[O:25])=[CH:22][CH:21]=4)[CH2:17][C:18]#[CH:19])[C:7]=3[CH:8]=2)[N:3]=1

Participants

4

Reactant 3

HCID 13041PentafluorophenolHCID 135443466p-[N-((6RS)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoic acidHCID 135462847HCID 135462847, compound

Product 1

HCID 135480233HCID 135480233, compound

Procedure

Using an analogous procedure to that described in section (3) of Example 5 p-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoic acid was reacted with pentafluorophenol to give pentafluorophenyl p-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta-[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoate.

Sources & evidence

ORD record
ord-7afe7d9635fc4ec5882ad7246a883cae
Source dataset
uspto-grants-1998_05
Patent number
US05747499

Reaction notes

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