Methyl alpha-amino-p-methoxycarbonylmethylphenylacetate → (RS)-alpha-amino-p-carboxymethylphenylacetic acid

Participants

Reaction Steps

A suspension of methyl α-amino-p-methoxycarbonylmethylphenylacetate (2.3 g, 7 mmol) in 60 ml of 6N HCl was refluxed for 12 hours. After cooling white needles were collected. The aqueous layers were extracted with ethyl acetate. The organic layers were evaporated and the solids combined to give (RS)-α-amino-p-carboxymethylphenylacetic acid (1.45 g, 83%);

Provenance & Evidence