反应详情

A suspension of methyl α-amino-p-methoxycarbonylmethylphenylacetate (2.3 g, 7 mmol) in 60 ml of 6N HCl was refluxed for 12 hours. After cooling white needles were collected. The aqueous layers were extracted with ethyl acetate. The organic layers were evaporated and the solids combined to give (RS)-α-amino-p-carboxymethylphenylacetic acid (1.45 g, 83%);

1. temperaturewas refluxed for 12 hours
2. temperatureAfter cooling white needles
3. customwere collected
4. extractionThe aqueous layers were extracted with ethyl acetate
5. customThe organic layers were evaporated