反应详情

50 g of N-chlorosuccinimide are added in portions at 23° C. to a solution of 45 g of 2,4-diamino-6-chloropyrimidine in methanol (1030 ml). On completion of addition, the reaction mixture is stirred at room temperature for 3 hours. The methanol is evaporated under reduced pressure and the crude product obtained is taken up under reflux in 850 ml of water for 1 hour. After filtering, the crude product is recrystallized two times from an EtOH:H2O (80:20) mixture to give 44.5 g of 2,4-diamino-5,6-dichloropyrimidine.

1. additionOn completion of addition
2. customThe methanol is evaporated under reduced pressure
3. customthe crude product obtained
4. filtrationAfter filtering
5. customthe crude product is recrystallized two times from an EtOH:H2O (80:20) mixture