HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 4-(Decyloxy)-3-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Decyloxy-3-fluorophenyl bromide | HCID 14692509 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(Decyloxy)-3-fluorobenzoic acid | HCID 639974 | — |
Reaction Steps
A solution of n-butyllithium was added dropwise to a stirred, cooled (-78° C.) solution of compound of step 2.1 in dry THF. The mixture was maintained under these conditions for 40 mins and then poured into a slurry of dry ether and cardice. The solution was acidified with 36% HCl, washed with water and dried (magnesium sulphate). The solvent was removed to yield a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750050 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-1090e088da22497eb8bcb2419e46c059 |
| Source note | uspto-grants-1998_05 |