Methanol → Methyl 3-Hydroxybenzoate

HRID 1289341Notes

Reaction equation

HRID 1289341 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH3:16]O>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([O:7][CH3:16])=[O:6]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 74203-Hydroxybenzoic Acid

Product 1

HCID 88068Methyl 3-Hydroxybenzoate

Procedure

3-hydroxybenzoic acid (30.0 g, 0.22 mol), methanol (101 ml) and concentrated sulphuric acid (2.7 ml) were added together and heated under reflux for 4 h. The reaction mixture was allowed to cool and the methanol was removed. The crude product was dried in vacuo and used without further purification.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 4 h
  3. temperatureto cool
  4. customthe methanol was removed
  5. dry with materialThe crude product was dried in vacuo
  6. customused without further purification

Sources & evidence

ORD record
ord-7785aeff8eeb46f79272c3b4fd31b015
Source dataset
uspto-grants-1998_05
Patent number
US05750050

Reaction notes

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