HCID 23206536, compound → HCID 23206542, compound

HRID 1289430Notes

Reaction equation

HRID 1289430 reaction equation
[CH2:1]([O:3][P:4]([C:9]1[CH:10]=[N:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=2)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]>C(O)(=O)C>[CH2:6]([O:5][P:4]([CH:9]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:19]([F:20])([F:21])[F:22])[CH:16]=2)[NH:11][CH2:10]1)(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

Participants

3

Reactant 1

HCID 23206536HCID 23206536, compound

Product 1

HCID 23206542HCID 23206542, compoundYield 52.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6.66 g of 6-trifluoromethyl-quinoline-3-phosphonic acid diethyl ester is dissolved in 70 ml of glacial acetic acid and hydrogenated on platinum dioxide at room temperature under normal pressure. After column chromatography, 3.52 g of 6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-3-phosphonic acid diethyl ester of melting point 112° C. is obtained.

Sources & evidence

ORD record
ord-a86a790e0855438498c4143e46d7b22d
Source dataset
uspto-grants-1998_05
Patent number
US05750526

Reaction notes

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