2,5-Dimethoxytetrahydrofuran → HCID 23206551, compound

HRID 1289435Notes

Reaction equation

HRID 1289435 reaction equation
[CH2:1]([O:3][P:4]([CH:9]1[N:14]2[C:15](=[O:28])[C:16](=[O:27])[NH:17][C:18]3[CH:19]=[C:20]([C:23]([F:26])([F:25])[F:24])[C:21]([NH2:22])=[C:12]([C:13]=32)[CH2:11][CH2:10]1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].CO[CH:31]1[CH2:35][CH2:34][CH:33](OC)O1>>[CH2:6]([O:5][P:4]([CH:9]1[N:14]2[C:15](=[O:28])[C:16](=[O:27])[NH:17][C:18]3[CH:19]=[C:20]([C:23]([F:26])([F:25])[F:24])[C:21]([N:22]4[CH:31]=[CH:35][CH:34]=[CH:33]4)=[C:12]([C:13]=32)[CH2:11][CH2:10]1)(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

Participants

3

Reactant 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 23206547HCID 23206547, compound

Product 1

HCID 23206551HCID 23206551, compound

Procedure

211 mg of 8-amino-9-trifluoromethyl-2,3-dioxo-1,2,3,5,6,7-hexahydro-pyrido[1,2,3-de]quinoxaline-5-phosphonic acid diethyl ester and 66 mg of 2,5-dimethoxytetrahydrofuran are reacted for one hour at 140° C. bath temperature. After recrystallization from ethanol, 123 mg of 8-(1-pyrrolyl)-9-trifluoromethyl-2,3-dioxo-1,2,3,5,6,7-hexahydro-pyrido[1,2,3-de]quinoxaline-5-phosphonic acid diethyl ester of melting point 268° C. is obtained.

Workup

  1. customAfter recrystallization from ethanol, 123 mg of 8-(1-pyrrolyl)-9-trifluoromethyl-2,3-dioxo-1,2,3,5,6,7-hexahydro-pyrido[1,2,3-de]quinoxaline-5-phosphonic acid diethyl ester of melting point 268° C.
  2. customis obtained

Sources & evidence

ORD record
ord-a72a2a7e807341199b9b3b9e728baa5f
Source dataset
uspto-grants-1998_05
Patent number
US05750526

Reaction notes

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