Phenylmethyl 4-(2,3-dihydro-1H-inden-2-yl)-2-butenoate → HCID 10465518, compound

HRID 1289442Notes

Reaction equation

HRID 1289442 reaction equation
C([O:8][C:9](=[O:22])[CH:10]=[CH:11][CH2:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1)C1C=CC=CC=1>CO.[C].[Pd]>[CH2:21]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH:13]1[CH2:12][CH2:11][CH2:10][C:9]([OH:22])=[O:8]

Participants

4

Reactant 1

HCID 54078263Phenylmethyl 4-(2,3-dihydro-1H-inden-2-yl)-2-butenoate

Product 1

HCID 10465518HCID 10465518, compoundYield 85.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Dissovled in 120 ml of methanol were 6.45 g (22.1 mmol) of benzyl-4-(indan-2-yl)-2-butenoate, and 0.6 g of 10% palladium-carbon was added to the solution, followed by vigorous stirring for 2.5 hours under a hydrogen atmosphere. The catalyst was separated by filtration, and the filtrate was concentrated to obtain 3.84 g of 4-(indan-2-yl)butanoic acid as a crystal. Yield: 85%.

Workup

  1. additionwas added to the solution
  2. customThe catalyst was separated by filtration
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-d6a1fa13c10e41628c1ab483f2ec156e
Source dataset
uspto-grants-1998_05
Patent number
US05750524

Reaction notes

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