Water → HCID 18921531, compound

HRID 1289443Notes

Reaction equation

HRID 1289443 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]1[CH2:16][C:17]([NH2:19])=O.O.[OH-].[Na+]>O1CCCC1>[CH2:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:7][CH:8]1[CH2:16][CH2:17][NH2:19]

Participants

6

Reactant 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 189215242-(2,3-Dihydro-1H-inden-2-yl)acetamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 18921531HCID 18921531, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Suspended in 400 ml of tetrahydrofuran were 8.77 g (0.23 mol) of lithium aluminum hydride, and a suspension of 27.8 g (0.160 mol) of (indan-2-yl)acetamide in 100 ml of tetrahydro-furan was added under chilling with ice water. After stirring for 30 minutes at room temperature, the suspension mixture was refluxed for 5 hours. While chilling with ice water, 9 ml of water, 9 ml of 15% sodium hydroxide and 26 ml of water were added dropwise in that order to decompose excess of the reagents. Solids were separated by filtration, and the filtrate was concentrated, thereby obtaining 26.1 g of an oily substance. Yield: 100%.

Workup

  1. additionwas added
  2. temperaturethe suspension mixture was refluxed for 5 hours
  3. additionwere added dropwise in that order
  4. customSolids were separated by filtration
  5. concentrationthe filtrate was concentrated
  6. customobtaining 26.1 g of an oily substance

Sources & evidence

ORD record
ord-40b9d701f9584e43ae4a731c9221e5a2
Source dataset
uspto-grants-1998_05
Patent number
US05750524

Reaction notes

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