Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]-acetate | HCID 15290059 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 146737-36-2 | HCID 219052 | 91.1% |
Reaction Steps
Suspended in 50 ml of 1N sodium hydroxide were 16.5 g of ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]-acetate, and the suspension was heated at 80° C. for 1 hour. After cooling, hydrochloric acid was added to the suspension to acidify it. A crystal deposited was collected by filtration. The crystal was recrystallized from 80% ethanol to obtain 14.0 g of the title compound as a colorless needle crystal. Yield: 91%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05750524 |
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| Source dataset | uspto-grants-1998_05 |
|---|
| ORD ID | ord-67c086265d0548679f845e1f55e173e0 |
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| Source note | uspto-grants-1998_05 |
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