Hydrochloric Acid → 146737-36-2

HRID 1289445Notes

Reaction equation

HRID 1289445 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([CH2:22][C:23]([O:25]CC)=[O:24])[CH:19]=3)[CH2:14]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl>[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH2:12][CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([CH2:22][C:23]([OH:25])=[O:24])[CH:19]=3)[CH2:14]2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15290059Ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]-acetate

Product 1

HCID 219052146737-36-2Yield 91.1%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
80 °C

Procedure

Suspended in 50 ml of 1N sodium hydroxide were 16.5 g of ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]-acetate, and the suspension was heated at 80° C. for 1 hour. After cooling, hydrochloric acid was added to the suspension to acidify it. A crystal deposited was collected by filtration. The crystal was recrystallized from 80% ethanol to obtain 14.0 g of the title compound as a colorless needle crystal. Yield: 91%.

Workup

  1. temperatureAfter cooling
  2. filtrationA crystal deposited was collected by filtration
  3. customThe crystal was recrystallized from 80% ethanol

Sources & evidence

ORD record
ord-67c086265d0548679f845e1f55e173e0
Source dataset
uspto-grants-1998_05
Patent number
US05750524

Reaction notes

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