Succinic anhydride → HCID 18921492, compound

HRID 1289450Notes

Reaction equation

HRID 1289450 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([NH:15][CH2:16][CH:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1.[C:26]1(=[O:32])[O:31][C:29](=[O:30])[CH2:28][CH2:27]1>ClC(Cl)C>[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([S:12]([NH:15][CH2:16][CH:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[CH:23]=3)[CH2:18]2)(=[O:14])=[O:13])=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 7922Succinic anhydrideHCID 6451240Aluminum(III) ChlorideHCID 189215132-[(4-Chlorophenyl)sulfonylaminomethyl)indan

Product 1

HCID 18921492HCID 18921492, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Suspended in 35 ml of dichloroethane were 6.82 g (51.2 mmol) of anhydrous aluminum chloride, and 4.26 g (13.3 mmol) of 2-[(4-chlorophenyl)sulfonylaminomethyl]indane prepared in Referential Example 1 were added thereto. While chilling with ice water, 2.07 g (20.6 mmol) of succinic anhydride were added to this suspension in small portions. Thereafter, the mixture was stirred at room temperature for 1.5 hours, and the liquid reaction mixture was poured into ice water. A crystal deposited was collected by filtration, washed with water and then recrystallized from acetic acid to obtain 4.75 g of a colorless crystal. Yield: 85%.

Workup

  1. customprepared in Referential Example 1
  2. additionwere added
  3. additionwere added to this suspension in small portions
  4. customthe liquid reaction mixture
  5. filtrationA crystal deposited was collected by filtration
  6. washwashed with water
  7. customrecrystallized from acetic acid

Sources & evidence

ORD record
ord-c6994898ee55417da67413f23181e552
Source dataset
uspto-grants-1998_05
Patent number
US05750524

Reaction notes

Loading…