HCID 17800767, compound → HCID 21847700, compound

HRID 1289456Notes

Reaction equation

HRID 1289456 reaction equation
C([O:3][P:4]([CH2:9][N:10]1[C:19]2[C:14](=[CH:15][C:16]([N:23]3[CH:27]=[CH:26][N:25]=[CH:24]3)=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=2)[NH:13][C:12](=[O:28])[C:11]1=[O:29])(=[O:8])[O:5]CC)C>Cl>[N:23]1([C:16]2[CH:15]=[C:14]3[C:19](=[CH:18][C:17]=2[N+:20]([O-:22])=[O:21])[N:10]([CH2:9][P:4]([OH:5])(=[O:3])[OH:8])[C:11](=[O:29])[C:12](=[O:28])[NH:13]3)[CH:27]=[CH:26][N:25]=[CH:24]1

Participants

3

Reactant 1

HCID 17800767HCID 17800767, compound

Product 1

HCID 21847700HCID 21847700, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

250 mg of [(6-(N-imidazolyl)-7-nitro-1,2,3,4-tetrahydro-2,3-dioxoquinoxalin-1-yl)methanephosphonic acid diethyl ester is heated in 3 ml of concentrated hydrochloric acid for 2.5 hours to 110° C. bath temperature. After concentration by evaporation, it is taken up in water, and the precipitated product is suctioned off. 100 mg of [6-(N-imidazolyl)-7-nitro-1,2,3,4-tetrahydro-2,3-dioxoquinoxalin-1-yl]methanephosphonic acid is obtained.

Workup

  1. concentrationAfter concentration
  2. customby evaporation, it

Sources & evidence

ORD record
ord-f433f1d76a7949bfb2c89bc19fcf1247
Source dataset
uspto-grants-1998_05
Patent number
US05750525

Reaction notes

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