5-Nitrofurfural → HCID 18921656, compound

HRID 1289472Notes

Reaction equation

HRID 1289472 reaction equation
Cl.[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5][SH:6].[H-].[Na+].[N+]([C:13]1[O:17][C:16]([CH:18]=[O:19])=[CH:15][CH:14]=1)([O-])=O>CS(C)=O>[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5][S:6][C:13]1[O:17][C:16]([CH:18]=[O:19])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 127745-NitrofurfuralHCID 24758Sodium hydrideHCID 25798Captamine Hydrochloride

Product 1

HCID 18921656HCID 18921656, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2-Dimethylaminoethanethiol hydrochloride was suspended in dry DMSO and sodium hydride was added. The reaction mixture was left stirring for 40 minutes before 5-nitro-2-furancarboxaldehyde was added. The reaction mixture was allowed to stir for 30 minutes at room temperature, to give the title compound. This is the starting aldehyde used in the synthesis of compound 5253.

Workup

  1. waitThe reaction mixture was left
  2. additionwas added

Sources & evidence

ORD record
ord-7863ee0f3ae542d48883e35032e826bf
Source dataset
uspto-grants-1998_05
Patent number
US05750530

Reaction notes

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