反应详情

A mixture solution of chloroacetic acid(33.3 g, 0.352 mol), water(400 ml) and 2-mercapto-6-ethylpyrimidine-4-one(29 g, 0.186 mol) prepared in the above Step 1 was heated to reflux for 14 hours and cooled to a room temperature. To the reaction mixture was added conc. HCl(95 ml) and the mixture was heated to reflux for 1 day. After the reaction mixture was cooled to a room temperature and concentrated under a reduced pressure, the residue was diluted with water. After stirring for 2 hours, the resulting solid was filtered and dried to give 11.16 g of the titled compound. (Yield: 43%)

1. temperaturewas heated
2. temperatureto reflux for 14 hours
3. temperaturethe mixture was heated
4. temperatureto reflux for 1 day
5. temperatureAfter the reaction mixture was cooled to a room temperature
6. concentrationconcentrated under a reduced pressure
7. additionthe residue was diluted with water
8. filtrationthe resulting solid was filtered
9. customdried