反应详情

A mixture of phosphorous oxychloride(43 ml), N,N-dimethyl aniline(6.6 ml) and 2,4-dihydroxy-6-ethyl pyrimidine(11.12 g, 79.3 mmol) prepared in the above Step 2 was heated to reflux for 6 hours. The reaction mixture was cooled to a room temperature and diluted with dichloromethane. The diluted solution was added slowly to ice water, while maintaining the temperature of the reaction system below 10° C. and the mixture was extracted with dichloromethane. The combined dichloromethane layers were dried over magnesium sulfate and concentrated to give 13.10 g of the titled compound as an oily form. (Yield: 93.3%)

1. customprepared in the above Step 2
2. temperaturewas heated
3. temperatureto reflux for 6 hours
4. temperaturewhile maintaining the temperature of the reaction system below 10° C.
5. extractionthe mixture was extracted with dichloromethane
6. dry with materialThe combined dichloromethane layers were dried over magnesium sulfate
7. concentrationconcentrated