4-Fluoroaniline → HCID 18921749, compound

HRID 1289503Notes

Reaction equation

HRID 1289503 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH2:9]([C:11]1[N:16]=[C:15]([Cl:17])[N:14]=[C:13]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]2[CH3:28])[CH:12]=1)[CH3:10]>CN(C)C=O>[ClH:17].[CH2:9]([C:11]1[N:16]=[C:15]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=2)[N:14]=[C:13]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]2[CH3:28])[CH:12]=1)[CH3:10]

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921765HCID 18921765, compound

Product 1

HCID 18921749HCID 18921749, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.38 ml, 4.01 mmol) was added to a mixture solution of 6-ethyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloropyrimidine (0.57 g, 1.98 mmol) and dimethylformamide (5 ml), 0.17 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1

Sources & evidence

ORD record
ord-e5fc0bf9bc2b44acaef3be74d526c069
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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