4-Fluoroaniline → HCID 18921676, compound

HRID 1289507Notes

Reaction equation

HRID 1289507 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][CH:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1[CH:25]=[C:24]([CH2:26][CH2:27][CH3:28])[N:23]=[C:22]([Cl:29])[N:21]=1>CN(C)C=O>[ClH:29].[CH3:9][CH:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1[CH:25]=[C:24]([CH2:26][CH2:27][CH3:28])[N:23]=[C:22]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=2)[N:21]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921736HCID 18921736, compound

Product 1

HCID 18921676HCID 18921676, compoundYield 43.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.27 ml, 2.85 mmol) was added to a mixture solution of 4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-6-propyl-2-chloropyrimidine(0.5 g, 1.66 mmol) and dimethylformamide(5 ml), 0.3 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-8011eea68bfa4e8384e96f3df320de95
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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