Aniline → HCID 18921671, compound

HRID 1289519Notes

Reaction equation

HRID 1289519 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][C:9]1[C:10]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]2[CH3:27])=[N:11][C:12]([Cl:16])=[N:13][C:14]=1[CH3:15]>CN(C)C=O>[ClH:16].[CH3:8][C:9]1[C:10]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]2[CH3:27])=[N:11][C:12]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:13][C:14]=1[CH3:15]

Participants

4

Reactant 2

HCID 6115AnilineHCID 111853185,6-Dimethyl-2-chloro4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

Product 1

HCID 18921671HCID 18921671, compoundYield 22.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After aniline(0.53 ml, 5.5 mmol) was added to a mixture solution of 5,6-dimethyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloropyrimidine(0.72 g, 2.5 mmol) and dimethylformamide(5 ml), 0.21 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-84a90b72171f4591941a6f83dbd25b15
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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