1-Methyl-1,2,3,4-tetrahydroisoquinoline → HCID 18921790, compound

HRID 1289522Notes

Reaction equation

HRID 1289522 reaction equation
C[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][NH:3]1.[Cl:12][C:13]1[N:18]=[C:17](Cl)[C:16]([CH3:20])=[C:15]([CH2:21][CH3:22])[N:14]=1>>[CH3:20][C:16]1[C:17]([N:3]2[CH2:4][CH2:5][C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:2]2)=[N:18][C:13]([Cl:12])=[N:14][C:15]=1[CH2:21][CH3:22]

Participants

3

Reactant 2

HCID 922141-Methyl-1,2,3,4-tetrahydroisoquinolineHCID 18921712HCID 18921712, compound

Product 1

HCID 18921790HCID 18921790, compoundYield 56.7%

Procedure

In accordance with the same procedure as in Step 1 of Example 1, except that 1-methyl-1,2,3,4-tetrahydroisoquinoline (2.3 g, 15.6 mmol) and 2,4-dichloro-5-methyl-6-ethylpyrimidine (2.7 g, 14.1 mmol) prepared in Preparation 4 were used as starting materials, 2.3 g of the titled compound was prepared. (Yield: 54%)

Sources & evidence

ORD record
ord-0d74cf8bf5474b829d525eb5bd1c2b44
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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