Hydrochloric Acid → HCID 178518296, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture solution of 20% HCl(62 ml) and 2-amino-4-hydroxycyclopenta[d]pyrimidine (20.6 g, 0.136 mol) prepared in the above Step 1 was added aqueous solution of sodium nitrite (19.4 g) for 4 hours while keeping the temperature of the reaction system at 70° C. The reaction mixture was cooled to 0° C. and the resulting solid was filtered, dried under reduced pressure to give 15.43 g of titled compound.

Provenance & Evidence