Hydrochloric Acid → HCID 178518296, compound

HRID 1289527Notes

Reaction equation

HRID 1289527 reaction equation
Cl.N[C:3]1[NH:8][C:7]2=[CH:9][CH:10]=[CH:11][C:6]2=[C:5]([OH:12])[N:4]=1.N([O-])=[O:14].[Na+]>>[OH:14][C:3]1[NH:8][C:7]2=[CH:9][CH:10]=[CH:11][C:6]2=[C:5]([OH:12])[N:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 18921702HCID 18921702, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 178518296HCID 178518296, compoundYield 75.6%

Conditions

Temperature
0 °C

Procedure

To a mixture solution of 20% HCl(62 ml) and 2-amino-4-hydroxycyclopenta[d]pyrimidine (20.6 g, 0.136 mol) prepared in the above Step 1 was added aqueous solution of sodium nitrite (19.4 g) for 4 hours while keeping the temperature of the reaction system at 70° C. The reaction mixture was cooled to 0° C. and the resulting solid was filtered, dried under reduced pressure to give 15.43 g of titled compound.

Workup

  1. customat 70° C
  2. filtrationthe resulting solid was filtered
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-8b7db1dd71f34c5892e48599ab31b2a3
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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