4-Fluoro-2-methylaniline → HCID 18921686, compound

HRID 1289530Notes

Reaction equation

HRID 1289530 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][CH:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][N:12]1[C:21]1[N:26]=[C:25]([Cl:27])[NH:24][C:23]2=[CH:28][CH:29]=[CH:30][C:22]=12>CN(C)C=O>[ClH:27].[CH3:9][C:4]1[CH:3]=[C:2]([F:1])[CH:8]=[CH:7][C:5]=1[NH:6][C:25]1[NH:24][C:23]2=[CH:28][CH:29]=[CH:30][C:22]2=[C:21]([N:12]2[CH2:13][CH2:14][C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:11]2[CH3:10])[N:26]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921721HCID 18921721, compound

Product 1

HCID 18921686HCID 18921686, compoundYield 20.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoro-2-methylaniline(0.40 ml, 3.60 mmol) was added to a mixture solution of 4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chlorocyclopenta[d]pyrimidine (0.50 g, 1.70 mmol) and dimethylformamide(5 ml), 0.15 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-f89954407ec745c7ba99c9a39a050d05
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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