4-Fluoroaniline → HCID 18921738, compound

HRID 1289531Notes

Reaction equation

HRID 1289531 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][CH:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1[N:25]=[C:24]([Cl:26])[NH:23][C:22]2=[CH:27][CH:28]=[CH:29][C:21]=12>CN(C)C=O>[ClH:26].[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:24]2[NH:23][C:22]3=[CH:27][CH:28]=[CH:29][C:21]3=[C:20]([N:11]3[CH2:12][CH2:13][C:14]4[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:10]3[CH3:9])[N:25]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921721HCID 18921721, compound

Product 1

HCID 18921738HCID 18921738, compoundYield 13.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.40 ml, 4.2 mmol) was added to a mixture solution of 4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-yl)-2-chlorocyclopenta[d]pyrimidine(0.60 g, 2.0 mmol) and dimethylformamide(5 ml), 0.11 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-1a9a2e1c39664652885decccbf0eec10
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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