4-Fluoroaniline → HCID 18921757, compound

HRID 1289557Notes

Reaction equation

HRID 1289557 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH2:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][N:10]1[C:19]1[C:28]2[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=2[N:22]=[C:21]([Cl:29])[N:20]=1>CN(C)C=O>[ClH:29].[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:21]2[N:20]=[C:19]([N:10]3[CH2:11][CH2:12][C:13]4[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH2:9]3)[C:28]3[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=3[N:22]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921761HCID 18921761, compound

Product 1

HCID 18921757HCID 18921757, compoundYield 50.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.60 ml, 6.3 mmol) was added to a mixture solution of 4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloro-5,6,7,8-tetrahydroquinazoline(0.90 g, 3.0 mmol) and dimethylformamide(5 ml), 0.62 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-da8ca6fe164c442888dc8f766504d2ee
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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