2,4-Dichloro-6-methylpyrimidine → HCID 18921666, compound

HRID 1289560Notes

Reaction equation

HRID 1289560 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][CH:11]1[C:16]2[S:17][CH:18]=[CH:19][C:15]=2[CH2:14][CH2:13][NH:12]1>>[CH3:9][C:4]1[N:3]=[C:2]([Cl:1])[N:7]=[C:6]([N:12]2[CH2:13][CH2:14][C:15]3[CH:19]=[CH:18][S:17][C:16]=3[CH:11]2[CH3:10])[CH:5]=1

Participants

3

Reactant 2

HCID 794712,4-Dichloro-6-methylpyrimidineHCID 145481697-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Product 1

HCID 18921666HCID 18921666, compoundYield 41.4%

Procedure

In accordance with the same procedure as in Step 1 of Example 1, except that 2,4-dichloro-6-methylpyrimidine(3.1 g, 19 mmol) and 7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (2.9 g, 19 mmol) in Preparation 1 were used as starting materials, 2.2 g of the titled compound was obtained as white crystal. (Yield: 41%)

Sources & evidence

ORD record
ord-c5300c6cd8394a5085b4d09e92e796fc
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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