Sodium Hydroxide → HCID 178429342, compound

HRID 1289568Notes

Reaction equation

HRID 1289568 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4](Cl)[CH:3]=1.[OH-:10].[Na+]>O1CCCC1>[CH3:1][C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([OH:10])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 794712,4-Dichloro-6-methylpyrimidine

Product 1

HCID 178429342HCID 178429342, compoundYield 66.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a mixture solution of 6-methyl-2,4-dichloropyrimidine (25 g, 0.153 mol) in tetrahydrofurane(170 ml) was added 1N-NaOH solution(420 ml) and stirred for 48 hours at room temperature. The reaction mixture was washed with ethyl ether to remove impurities, acidified with hydrochloric acid, and then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure to give 13.5 g of titled compound as yellow solid form. (Yield: 66.7%)

Workup

  1. washThe reaction mixture was washed with ethyl ether
  2. customto remove impurities
  3. extractionextracted with ethyl acetate
  4. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-0fca51e466a9418ba0c7ff566522a636
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

Loading…