4-Fluoro-2-methylaniline → HCID 18921659, compound

HRID 1289574Notes

Reaction equation

HRID 1289574 reaction equation
[CH3:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:10][C:11]1[N:16]=[C:15]([N:17]2[CH2:22][CH2:21][C:20]3[CH:23]=[CH:24][S:25][C:19]=3[CH:18]2[CH3:26])[N:14]=[C:13]([Cl:27])[CH:12]=1>CN(C)C=O>[ClH:27].[CH3:10][C:11]1[N:16]=[C:15]([N:17]2[CH2:22][CH2:21][C:20]3[CH:23]=[CH:24][S:25][C:19]=3[CH:18]2[CH3:26])[N:14]=[C:13]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:2]=2[CH3:1])[CH:12]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921750HCID 18921750, compound

Product 1

HCID 18921659HCID 18921659, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 2-methyl-4-fluoroaniline(0.38 ml, 3.42 mmol) was added to a mixture solution of 6-methyl-2-(7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-yl)-4-chloropyrimidine (0.5 g, 1.8 mmol) and dimethylformamide(10 ml), 0.35 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-a90e938cf7784045bebbc6980768d2d3
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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