4-Fluoroaniline → HCID 18921794, compound

HRID 1289575Notes

Reaction equation

HRID 1289575 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][C:10]1[N:15]=[C:14]([N:16]2[CH2:21][CH2:20][C:19]3[CH:22]=[CH:23][S:24][C:18]=3[CH:17]2[CH3:25])[N:13]=[C:12]([Cl:26])[CH:11]=1>CN(C)C=O>[ClH:26].[CH3:9][C:10]1[N:15]=[C:14]([N:16]2[CH2:21][CH2:20][C:19]3[CH:22]=[CH:23][S:24][C:18]=3[CH:17]2[CH3:25])[N:13]=[C:12]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921750HCID 18921750, compound

Product 1

HCID 18921794HCID 18921794, compoundYield 42.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.26 ml, 2.74 mmol) was added to a mixture solution of 6-methyl-2-(7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-yl)-4-chloropyrimidine(0.5 g, 1.8 mmol) and dimethylformamide(10 ml), 0.30 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-4665f74d7ee944f4b7d8957115899798
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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