1-Methyl-1,2,3,4-tetrahydroisoquinoline → HCID 178436951, compound

HRID 1289576Notes

Reaction equation

HRID 1289576 reaction equation
[CH2:1]([C:3]1[N:8]=[C:7](Cl)[N:6]=[C:5]([OH:10])[CH:4]=1)[CH3:2].[CH3:11][CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][NH:13]1>>[CH2:1]([C:3]1[N:8]=[C:7]([N:13]2[CH2:14][CH2:15][C:16]3[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:12]2[CH3:11])[N:6]=[C:5]([OH:10])[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 922141-Methyl-1,2,3,4-tetrahydroisoquinolineHCID 178436946HCID 178436946, compound

Product 1

HCID 178436951HCID 178436951, compoundYield 80.2%

Procedure

In accordance with the same procedure as in Step 2 of Example 57, except that 6-ethyl-2-chloro-4-hydroxypyrimidine (7.0 g, 37.5 mmol) prepared in the above Step 1 and 1-methyl-1,2,3,4-tetrahydroisoquinoline(11.04 g, 75 mmol) were used as starting materials, 8.1 g of the titled compound was prepared. (Yield: 80%)

Sources & evidence

ORD record
ord-e8079f0145504901a08e4e01ece2854d
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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