4-Fluoroaniline → HCID 18921755, compound

HRID 1289591Notes

Reaction equation

HRID 1289591 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][C:10]1[C:11]([Cl:27])=[N:12][C:13]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18]2)=[N:14][C:15]=1[CH3:16]>CN(C)C=O>[ClH:27].[CH3:9][C:10]1[C:11]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=2)=[N:12][C:13]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18]2)=[N:14][C:15]=1[CH3:16]

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921658HCID 18921658, compound

Product 1

HCID 18921755HCID 18921755, compoundYield 67.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.24 ml, 2.5 mmol) was added to a mixture solution of 5,6-dimethyl-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chloropyrimidine(0.33 g, 1.2 mmol) and dimethylformamide(10 ml), 0.31 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-a00743d8cb3f4cd5a2927b16e10474d0
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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