4-Fluoro-2-methylaniline → HCID 18921751, compound

HRID 1289593Notes

Reaction equation

HRID 1289593 reaction equation
[CH3:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:10][C:11]1[C:12]([Cl:28])=[N:13][C:14]([N:18]2[CH2:23][CH2:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]2[CH3:27])=[N:15][C:16]=1[CH3:17]>CN(C)C=O>[ClH:28].[CH3:10][C:11]1[C:12]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:2]=2[CH3:1])=[N:13][C:14]([N:18]2[CH2:23][CH2:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]2[CH3:27])=[N:15][C:16]=1[CH3:17]

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921734HCID 18921734, compound

Product 1

HCID 18921751HCID 18921751, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 2-methyl-4-fluoroaniline(0.3 ml, 3 mmol) was added to a mixture solution of 5,6-dimethyl-2-(7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-yl)-4-chloropyrimidine (0.4 g, 1.4 mmol) and dimethylformamide(10 ml), 0.14 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-8bec99f3edf142ed81798169d9579df0
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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