1,2,3,4-Tetrahydroisoquinoline → HCID 178517878, compound

HRID 1289600Notes

Reaction equation

HRID 1289600 reaction equation
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1.[CH2:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][NH:14]1>>[CH2:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][N:14]1[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 178517812HCID 178517812, compound

Product 1

HCID 178517878HCID 178517878, compoundYield 26.3%

Procedure

In accordance with the same procedure as in Step 2 of Example 57, except that 2-chloro-4-hydroxy-5,6,7,8-tetrahydroquinazoline (2.0 g, 10.8 mmol) prepared in Step 1 of Example 82 and 1,2,3,4-tetrahydroisoquinoline (2.8 g, 22.4 mmol) were used as starting materials, 0.8 g of the titled compound was prepared. (Yield: 26.3%)

Sources & evidence

ORD record
ord-3e896df6ba074ae6b4dad2beccc12ac2
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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