4-Fluoro-2-methylaniline → HCID 18921691, compound

HRID 1289601Notes

Reaction equation

HRID 1289601 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH2:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1[N:29]=[C:28]([Cl:30])[C:27]2[CH2:26][CH2:25][CH2:24][CH2:23][C:22]=2[N:21]=1>CN(C)C=O>[ClH:30].[CH3:9][C:4]1[CH:3]=[C:2]([F:1])[CH:8]=[CH:7][C:5]=1[NH:6][C:28]1[C:27]2[CH2:26][CH2:25][CH2:24][CH2:23][C:22]=2[N:21]=[C:20]([N:11]2[CH2:12][CH2:13][C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:10]2)[N:29]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921791HCID 18921791, compound

Product 1

HCID 18921691HCID 18921691, compoundYield 47.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoro-2-methylaniline(0.3 ml, 2.7 mmol) was added to a mixture solution of 2-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chloro-5,6,7,8-tetrahydroquinazoline(0.3 g, 1.0 mmol) and dimethylformamide(5 ml), 0.2 g of the titled compound was prepared in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-2530405a0c2042e5b7ab80bcae20412a
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

Loading…